Graded Assignment:  Week 7 – ( ) :  In cases if any websites or links do not work, select another respective exercise of choice to replace. ????When submitting work, be sure to include an APA cover page and include at least two APA formatted references (and APA in-text citations) to support the work this week.  Below is the general assessment rubric for this assignment and remember that late penalties are built within the overall assessment so complete this assignment by the Sunday due date of week 7. :  When I see similarity indexes over 20%, I will review the similarity report to determine if points are going to be docked for plagiarism issues and as a tip, do not include or write the actual questions or exercise directions within these papers. Assessment CriteriaPossible PointsPoints EarnedChapter 12: Questions for Discussion #1 through #35 Chapter 12: Exercise #1, #12, #1610 Chapter 13: Questions for Discussion #1 through #45 Chapter 13: Exercise #3, #4 and #610 A minimum of two sources of research is used10 Student included a paper professionally formatted using APA and free of grammar and spelling issues5 Student successfully completed and successfully submitted this paper by the Sunday due date.5 Comments:

Chapter 12: Questions for Discussion #1 through #3

1. Explain the differences between monogenic and polygenic diseases. Give examples of each.
Monogenic diseases are caused by mutations in a single gene and are typically inherited in a Mendelian fashion. These diseases are often rare and affect only a small proportion of the population. Examples of monogenic diseases include cystic fibrosis and sickle cell anemia.

On the other hand, polygenic diseases are influenced by multiple genes as well as environmental factors. They are much more common in the population and exhibit a complex inheritance pattern. Examples of polygenic diseases include diabetes, heart disease, and schizophrenia.

2. What is gene therapy? Discuss the potential benefits and limitations of gene therapy.
Gene therapy is an experimental technique that involves the insertion, deletion, or correction of specific genes in an individual’s cells to treat or prevent diseases. This can be done by delivering functional copies of genes into the patient’s cells or by modifying the patient’s own genes.

The potential benefits of gene therapy include the ability to treat genetic diseases at their source, potentially curing them or improving the patient’s quality of life. Gene therapy also holds promise for the treatment of cancer and other complex diseases.

However, gene therapy is still an emerging field and faces several challenges and limitations. One limitation is the difficulty of delivering genes to the target cells effectively and safely. Another limitation is the risk of unintended side effects or long-term consequences of gene manipulation. Additionally, gene therapy is currently expensive and not widely accessible, limiting its potential impact.

3. What are the ethical implications of gene therapy? Discuss the potential ethical concerns raised by this technology.
Gene therapy raises several ethical concerns that need to be carefully considered. One major concern is the potential for genetic enhancement, where gene therapy is used to improve traits beyond what is considered normal or necessary for health. This raises questions about fairness and equality, as well as the potential for creating a genetic divide in society.

Another ethical concern is the possibility of germline gene therapy, where genetic changes are made in reproductive cells that can be passed on to future generations. This raises questions about the potential unintended consequences and long-term effects of modifying the human genome.

There are also concerns about the informed consent process, the equitable distribution of gene therapies, and the potential for discrimination or stigmatization based on genetic information.

Overall, gene therapy holds great potential for improving health outcomes, but it is important to carefully consider the ethical implications and ensure that it is used responsibly and ethically.

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